News Update

19 December 2011 UK Patent Awarded Patent Serial Number GB2472315. To be announced in the Patents Journal on 18 January 2012.

Opening Statement

QSIant Limited was established in 2009 to develop next generation treatments for advanced periodontal disease based on the combination of quorum sensing inhibitors and antibacterials; and evaluate this approach for treating any biofilm diseases. Widening its applicability to human and veterinary medicine, agriculture, food processing and storage,and hygiene measures, amongst others.

Biofilms drive the development of periodontal disease and are highly resistant to antibacterials whilst complete mechanical removal is time consuming and difficult. Persistence of biofilm relies on bacterial interaction to produce its complex organisation. By successfully targeting these interactions the organisation falters, exposing weak, disoriented, and easily destroyed bacteria.

Quorum sensing is a major bacterial communication system. With its disruption bacteria act inappropriately, responding to a distorted view of their crowded environment by increasing activity, thereby becoming susceptible to antibacterials. Destruction of biofilm allows healing.

The company has identified a natural plant product containing high levels of active molecules. Combining this with antibacterials in a form suitable for application to periodontal pockets appears to produce healing significantly better than previous generations of adjunctive treatment.

Overview

The general state of gums and health

Periodontal disease is a progressive disease of the supporting structures of teeth caused by bacteria. We can go a stage further by saying it is caused by the organisational behaviour of groups of bacteria. It advances throughout life, varying over time and between individuals. It causes gradual loss of teeth and the supporting bone.

It has effects on general health, the degree of which is being earnestly studied. It is recognised that there are links with cardiovascular diseases, renal disease, respiratory disease, diabetes, some post-operative complications and even suggestions that it may promote pre-term births.

More obvious problems are bad breath, worsening appearance and function. What is clear is that effective treatment is required, preferably as soon as a person's predisposition is identified. Probably 3 out of every 10 people will develop the disease sufficient to cause tooth loss. We don't know the numbers involving the more general health effects, but these may be much higher, because long-term inflammatory response occurs years before tooth loss.

Signs of inflammation can be seen in 9 out of 10 people, when examined carefully. Most can change that by following simple advice, leaving perhaps 50% who need ongoing support and treatment.

 

An illustrative extreme example

Before treatment-diseased swollen gums

After treatment-healing gums

This is discussed on the results page

Click links (top left) to find out how it works, the science behind it, and results of treatment.

Introduction to this approach

For 70 years antibiotics have been used with considerable success. Increasingly we see unresponsive infections, particularly chronic ones perhaps with long term contibution to ill-health.

One is periodontal disease, affecting most people at some time during their lives, being the main cause of tooth loss, bringing with it a lack of confidence, embarassment, and feeling of premature aging, and reduced ability to eat a full range of foods.

Combining quorum sensing inhibitors in a new non-surgical approach to treating advanced gum disease, over 200 people have received this. This website gives information about this novel approach and results obtained.

Much research has been carried out to identify the 'cause(s)' of gum disease. Much emphasis has been placed on particular species of bacteria, and methods sought to selectively remove them.

Bacteria causing gum disease, rely on others to prepare the ground before they attack. This takes years to create suitable conditions . Once developed they are difficult to remove, even with professional help, so it's common to see gradual decline to tooth loss.

This novel approach resets conditions, including removing inflammation, so healing takes place. Development of fresh disease possibly takes several years, or longer, with good home care, such as brushing and flossing. Excellent home care may prevent its return, completely.

Click links (top left) to find out how it works, the science behind it, and results of treatment.

 

Dental professionals

Dental Professional Requests Further information [Click here]

People who think this approach may benefit them

Speak to your dentist about this and suggest they take a look at this website. If they feel it may benefit you, they may click the link above for further information.

If your dentist can't help you, please visit www.wharfdental.com